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This white paper reviews the clinical and research literatures on the impact of trauma in the context of urban poverty on the family system including the individual child or adult, adult intimate partnership, parent-child, siblings and intergenerational relationships, as well as the family as a whole. The purpose is to widen the trauma-informed care lens by focusing on familial responses to trauma and by building the foundational knowledge needed to design family centered, trauma-specific interventions that strengthen the family’s ability to adapt, cope and heal.