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The Annie E. Casey Foundation launched Family-Centered Community Change (FCCC) in 2012 to support three local partnerships seeking to help parents and children in high-poverty neighborhoods succeed together. Recognizing the roles that inequity and exclusion play in the communities’ economic and social conditions, Casey provided each FCCC initiative with trainings on racial and ethnic equity and inclusion (REEI) beginning in 2015. This brief describes three communities confronting these problems—Buffalo, Columbus, and San Antonio—and the lessons they are learning about what it might take to reach true REEI. We begin first with Casey’s focus on equity and inclusion and then explore the FCCC communities’ reflections on the REEI trainings they received and what both Casey and the communities have learned as they attempt to apply REEI in FCCC.