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In recent years, important attention has been paid to the concept of toxic stress and its impact on development. As scientific understanding of toxic stress grows, communities across the country are finding ways to prevent and respond to toxic stress in the lives of community members, particularly young children and their families. Six such communities are working together in the Early Childhood-LINC Learning Lab on Community Responses to Toxic Stress, facilitated by the Center for the Study of Social Policy. Building on the widely used definition of toxic stress from the Harvard Center for the Developing Child, the Learning Lab has worked to define what toxic stress is, why it is of concern and how communities can respond.